Head of Clinical Operations
Work for an Organization that brings innovative therapies to patients worldwide
VectorY combines the therapeutic potential of antibodies combined with AAV based delivery to develop long-lasting therapeutic solutions for neurodegenerative diseases of high unmet medical need. Founded in August 2020, and based in the Amsterdam Science Park, VectorY is a fully integrated precision medicines company focused on the development of innovative vectorized antibody therapies for the treatment of neurodegenerative diseases such as ALS and Huntington’s disease. The company has established a strong foundation for future growth having raised 160M euros in 2 financing rounds including a 129M euro series A round in November 2023 supported by a strong investor syndicate.
Short description of the position
The Head of Clinical Operations will play a key role within the company, overseeing the strategic and operational execution of all clinical activities. This individual will be accountable for the overall management, performance, and quality of clinical operations, ensuring that clinical programs are delivered on time, within budget, and to the highest standards. The ability to provide clear, concise updates to senior leadership and to guide clinical leads across multiple development programs is essential. Key responsibilities include oversight of project timelines, budgets, and resource allocation, as well as the evaluation and selection of CROs and clinical trial sites. The role requires close monitoring to ensure clinical strategies are effectively executed and that project deliverables meet quality expectations. Reporting directly to the Chief Medical Officer (CMO), the Head of Clinical Operations will work closely with cross-functional leaders to ensure alignment, effective communication, and seamless execution of clinical development plans).
Main responsibilities of the role
Lead all operational aspects of cross functional clinical programs, including strategic planning, communication, coordination, delegation, and stepping into direct action as necessary to make sure goals are achieved on time and on budget.
Vendor Management: Primary lead managing the Contract Research Organizations (CROs), vendors, and other third parties. Oversight of all clinical trial-related partners and vendors. Drive vendors to meet aggressive timelines, on budget, and hold them to account if they fall behind.
Patient Recruitment: Lead the operational strategy and execution for identifying, recruiting, and retaining trial subjects. Build strong relationships with Patient Advocacy groups.
Quality: In partnership with the VP Regulatory and head of QA, develop and continuously improve clinical SOPs and GCPs and provide oversight of clinical monitoring quality & adherence to established processes and plans in compliance with GCP.
Risk Management: Proactively identify potential risks and develop & implement action plans to avoid or mitigate program risks and make appropriate trade-offs of balancing risks with study deliverables and costs. Head of Clinical Operations.
Supply Management: Oversee and work collaboratively with vendor on clinical supply forecast and re-supply.
Skills and Qualifications
Master degree or PhD degree in Life Sciences. Project Management professional certificate is desirable.
Minimum 10 years of clinical operations management experience required.
Phase 1 through 3 global clinical trial management experience. Experience with trials for rare and common diseases in neurodegenerative disorders is preferred.
Advanced therapies (e.g. gene therapy) trial experience is required. Experience with invasive RoA treatment modalities is desirable.
Excellent understanding and demonstrated application of FDA guidelines, Good Clinical Practices (GCP), ICH and applicable Standard Operating Procedures.
Demonstrated ability and track record to recruit, manage, mentor, & train other operations team members in a positive and effective manner.
Demonstrated ability to manage CROs (and other vendors) to meet or exceed KPIs tied to corporate goals and hold them to account if they fall behind.
Ability to lead the clinical operations team, and collaborate with other internal colleagues, to achieve all elements of complex programs on timelines to meet or exceed corporate goals.
Ability to effectively communicate with and influence senior level stakeholders to gain buy-in on clinical strategy.
Project Management: expertise in managing complex projects with the ability to balance timelines, budgets, and quality.
Problem-Solving: strong analytical and critical thinking abilities with the capability to resolve issues and drive decisions in both scientific and business contexts.
Your Natural Strengths and Drivers
Strong organizational and communication skills.
Ability to build strong, collaborative and dynamic relationships with co-workers of diverse backgrounds and expertise.
Ability to function at a high level in a team setting whether leading the group or acting as an individual contributor.
Attention to detail and accuracy.
Ability to adapt to changing priorities and deadlines.
Self-starter with a high level of initiative.
Ability to remain focused and solution-oriented under pressure.
Focused on achieving results, with the ability to meet business goals.
Working at VectorY
Join us for meaningful, impactful work. Experience diverse and rewarding challenges where your contributions truly make a difference. We offer a competitive compensation package and a strong commitment to your professional growth. Be part of an authentic journey in a dynamic, ambitious biotech company dedicated to delivering innovative therapies to patients around the world.
Ready to make an impact? We’d love to hear from you. Please send your resume and motivation letter before 20 June 2025 to talent.acquisition@vectorytx.com, addressed to Sandra Lemmens.