Medical Director

Work for an Organization that brings innovative therapies to patients worldwide.

VectorY combines the therapeutic potential of antibodies combined with AAV based delivery to develop long-lasting therapeutic solutions for neurodegenerative diseases of high unmet medical need.

Founded in August 2020, and based in the Amsterdam Science Park, VectorY is a fully integrated precision medicines company focused on the development of innovative vectorized antibody therapies for the treatment of neurodegenerative diseases such as ALS and Huntington’s disease.

The company has established a strong foundation for future growth having raised 160m euros in 2 financing rounds including a 129m euro series A round in November 2023 supported by a strong investor syndicate.

Short description of the role

The Medical Director will serve as a clinical and scientific leader within the organization, providing strategic medical guidance for development programs in the Central Nervous System (CNS) therapeutic area. This role is responsible for contributing to the design, execution, and oversight of clinical development strategies, ensuring scientific excellence, patient safety, and regulatory compliance throughout program lifecycles. The ideal candidate has expertise in CNS disorders, hands-on experience in gene or cell therapy, and a strong understanding of early- to late-stage clinical development in the biotech industry. The Medical Director will report to the Chief Medical Officer.

Location: Boston, MA or Remote (US – East Coast)

Main responsibilities of the role:

  • Partner with cross-functional leaders (Clinical Operations, Regulatory Affairs, Science, CMC, etc.) to design and implement clinical development plans, study protocols, and endpoint strategies.

  • Partner with the Safety/Pharmacovigilance vendor, to monitor, assess and manage safety signals and ensure compliance with global safety regulations.

  • Present clinical updates to executive leadership, governance committees, and external stakeholders (e.g. DSMB).

  • Provide medical oversight for clinical trials, including eligibility criteria, safety monitoring, and data interpretation.

  • Support biomarker strategies and their implementation in clinical trials, patient-selection approaches, and translational science initiatives.

  • Contribute to the data analysis strategy and closely collaborate with biostatistics vendors.

  • Build and maintain strong relationships with key opinion leaders (KOLs), investigators, patient advocacy groups, and clinical partners globally.

  • Represent the company at scientific conferences, advisory boards, and medical congresses.

  • Foster open, proactive, and effective communication and build mutual respect across project teams to achieve transparency and clarity of program goals, progress, and issues.

  • Travel up to 25% time, based on program needs.

Skills and Qualifications:

  • MD or MD/PhD with board certification (Neurology or related discipline strongly preferred).

  • Minimum 3+ years of clinical development experience in the biotechnology or pharmaceutical industry.

  • Demonstrated expertise in CNS diseases - rare neurological disorders, neurodegenerative diseases, neuromuscular diseases, or related areas.

  • Direct experience with gene therapy, AAV-based programs, or other genetic medicine platforms strongly preferred.

  • Strong understanding of GCP, clinical trial methodology, regulatory frameworks, and drug development processes; experience with early-phase clinical trials and translational strategy preferred.

  • Strong knowledge of FDA and international regulatory requirements and guidelines with experience interfacing with relevant regulatory authorities (e.g., FDA, EMA).

  • Familiarity with companion diagnostics, biomarkers, and advanced neuroimaging modalities.

  • Excellent communication (verbal and written) and presentation skills.

  • Strong analytical and problem-solving skills and ability to work independently and manage multiple priorities in a fast-paced environment.

Your Natural Strengths and Drivers:

You are a senior medical leader who brings scientific credibility, strategic clarity and strong ownership to CNS development programs. You collaborate naturally across disciplines, make confident data-driven decisions, and represent VectorY with authority — always driven by patient impact and scientific excellence in a fast-moving biotech environment.

Working at VectorY

We offer a personal and authentic experience within a young, ambitious biotech company with an established and strong infrastructure on the path to bring innovative therapies to patients worldwide.

Interested? Please apply and send your resume before 26 April 2026 to talent.acquisition@vectorytx.com for the attention of Sandra Lemmens.

Apply now