Senior Scientist Pre-Clinical Translation – Biomarker Discovery

Work for an Organization that brings innovative therapies to patients worldwide.

VectorY combines the potential of antibodies and gene therapy to develop long-lasting therapeutic solutions for large disease areas of high unmet medical need.

Founded in August 2020, and based in the Amsterdam Science Park, VectorY is a fully integrated gene therapy company focused on the development of innovative therapeutics for the treatment of neurodegenerative diseases such as ALS and Huntington’s disease.

With R&D facilities in Amsterdam, VectorY develops proprietary & partnered programs based on its novel AAV-based vectorized antibody gene therapy platform.

Short description of the Research department

The Research Department develops new technologies and innovations in vectorized antibodies to develop novel treatments for neurodegenerative diseases, with a particular focus on CNS proteinopathies. We test new therapeutic candidates in both in vitro and in vivo pre-clinical models, aiming to translate these novel therapies into clinical practice.

We are looking for a Senior Scientist to join our Pre-Clinical Translation team. The ideal candidate will have expertise in biomarker discovery, a good understanding of neurodegenerative diseases, and a strong commitment to advancing drug development.

Main responsibilities of the role:

  • Develop a comprehensive scientific strategy and operational plan for the biomarker development.

  • Oversee the design and development of biomarker methods suitable for (pre)clinical activities.

  • Oversee and manage third parties for outsourced activities (e.g. CRO or CDMO). Secure that the activities are completed within set timelines and budget.

  • Establish and formalize collaborations with key opinion leaders, with focus on enhancing biomarker development strategies and leveraging external expertise.

  • Collaborate closely with cross‑functional teams, including Clinical, Manufacturing, and external partners such as CROs and academic collaborators, to drive cohesive and efficient project advancement.

  • Stay at the forefront of scientific and technological innovation by evaluating emerging methodologies and platforms, proactively introducing new approaches to strengthen translational and preclinical research strategies.

  • Writes, review and/or approve study plans and reports, and, if applicable, patents, articles and/or other documentation (e.g. regulatory).

Skills and Qualifications:

  • Ph.D. in Neurobiology or a related field with experience in neurodegenerative diseases (e.g., ALS, HD).

  • Extensive knowledge of design and execution of antibody-based assays (e.g. ELISA’s, MSD and SMC platforms) and analytical assays (mainly LC-MS) for biological matrices (CSF, blood, and tissues) in both pre-clinical and clinical settings.

  • Strong scientific acumen with the ability to lead experimental design and derive meaningful insights from complex datasets (e.g. Omics)

  • Effective organizational skills with the ability to manage multiple tasks, meet deadlines, and work both independently and collaboratively in a fast-paced environment.

  • Demonstrated success in collaborating with cross-functional teams and external partners, including CROs and academic institutions.

  • Excellent verbal and written communication skills in English.

Your Natural Strengths and Drivers:

  • Moves fast and takes ownership—drives work forward with urgency and follow-through.

  • Thinks creatively and challenges assumptions to unlock practical, high-impact solutions.

  • Collaborative and engaging mindset. that motivates others and collaborates across functions to get results.

  • Highly organized and execution-focused.Prioritizes smartly and keeps multiple workstreams on track.

  • Delivers accurate, reproducible experimental work and clean documentation.

  • Thrives in a fast-changing environment. Adapts quickly, resets priorities, and hits deadlines.

Working at VectorY

Challenging and varied work with a real impact. We offer an attractive salary package, 30 holiday days, and every opportunity to develop yourself. An authentic experience within a young, ambitious biotech company on the path to bringing innovative therapies to patients worldwide.

Interested? Please apply and send your resume before 15th May 2026 to talent.acquisition@vectorytx.com for the attention of Sandra Lemmens.

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