(Senior) Scientist Process Development 

Work for an Organization that brings innovative therapies to patients worldwide.

VectorY combines the therapeutic potential of antibodies combined with AAV based delivery to develop long-lasting therapeutic solutions for neurodegenerative diseases of high unmet medical need.  

Founded in August 2020, and based in the Amsterdam Science Park, VectorY is a fully integrated precision medicines company focused on the development of innovative vectorized antibody therapies for the treatment of neurodegenerative diseases such as ALS and Huntington’s disease. 

The company has established a strong foundation for future growth having raised 160M euros in 2 financing rounds including a 129M euro series A round in November 2023 supported by a strong investor syndicate. 

 

Short description of the position

At VectorY, we are pioneering vectorized antibody therapeutics to enable next-generation delivery of biologics. Using an AAV platform produced in insect cells, we are advancing novel treatments into clinical trials and beyond. 

Our Process Development department plays a central role in optimizing and scaling up manufacturing processes for these complex biologics. As we expand our pipeline and progress toward phase 3 readiness, we are seeking a highly motivated Scientist or Senior Scientist to support end-to-end process development and enable data-driven, clinical-grade AAV manufacturing.  

You will be at the forefront of developing and scaling up AAV manufacturing processes with a strong focus on building deep process insight through analytics. Your work will directly contribute to robust, scalable, and phase-appropriate processes that maintain the target drug product profile and quality. 

While we recognize most candidates bring deeper expertise in either upstream or downstream, we are specifically looking for someone with broad technical knowledge and a strong analytical mindset—capable of integrating data across process units to understand how critical process parameters influence product quality attributes. 

You will work cross-functionally with R&D, Analytical Development, Quality, and external CDMOs to implement Quality by Design (QbD) principles and leverage advanced data analytics tools to support process optimization and technology transfer. 

You will also have a people management component, overseeing one or more (Senior) Technicians who execute laboratory work and actively contribute to brainstorming, experimental design, data analysis, and reporting. We are looking for someone who values collaboration at all levels, and who can mentor and empower lab staff to take part in scientific and strategic discussions while ensuring efficient execution in the lab. 

Main responsibilities of the role 

  • Develop, optimize, and characterize AAV production processes using insect cell-based platforms (Sf9/Baculovirus system). 

  • Support both upstream (cell culture, infection, harvest) and downstream (purification, concentration, formulation) process development. 

  • Mentor and coach  

  • Design and analyse experiments using Design of Experiments (DoE) to identify and optimize critical process parameters (CPPs)  

  • Use multivariate data analysis (MVDA) and statistical modeling tools (e.g., SIMCA) to extract actionable insights on process variability and critical quality attributes (CQAs). 

  • Contribute to building integrated process control strategies that ensure product consistency and regulatory compliance 

  • Collaborate with cross-functional teams and external CDMOs to support process tech transfer, scale-up (from 50 L to 1000 L), and production of material for clinical trials. 

  • Prepare and review technical documentation to support internal decision-making and regulatory filings. 

  • Supervise and mentor one or more (Senior) Technicians and ensuring high-quality execution of lab work in alignment with project goals and timelines. 

Skills and Qualifications:

We’re looking for someone with: 

  • PhD in Biotechnology, Bioprocess Engineering, Biochemistry, or a related field. 

  • 3+ years (Scientist) or 5+ years (Senior Scientist) of relevant industry experience in AAV or biologics process development. 

  • Demonstrated knowledge of GMP manufacturing, tech transfer, and process scale-up to 500–1000 L or higher. 

  • Understanding of phase-appropriate CMC development and regulatory expectations for gene therapy products. 

  • Proven experience with data analytics in a process development context; hands-on use of DoE, MVDA, and QbD frameworks is highly valued. 

  • Solid understanding of how process parameters affect product quality, and a drive to uncover these relationships using data. 

  • Experience contributing to regulatory submissions and CMC strategy for gene therapy or complex biologics. 

  • Experience supervising or mentoring lab personnel, with an inclusive leadership style that encourages engagement beyond bench work (e.g., planning, data analysis, scientific discussions) 

Your Natural Strengths and Drivers 

Organized and efficient. 

  • Excellent data interpretation, documentation, and collaboration skills  

  • Flexible and comfortable with change and fast-paced work. 

  • Driven to deliver results. 

  • Strong communication skills.  

Working at VectorY

Challenging and varied work with a real impact. We offer an attractive salary package and every opportunity to develop yourself. An authentic experience within a young, ambitious biotech company on the path to bring innovative therapies to patients worldwide.  

Interested? Please apply and send your resume before 31 Aug 2025 to talent.acquisition@vectorytx.com addressed to Sandra Lemmens