(Sr.) Scientist BioAssay Development

Work for an Organization that brings innovative therapies to patients worldwide.

VectorY combines the potential of antibodies and gene therapy to develop long-lasting therapeutic solutions for large disease areas of high unmet medical need. Founded in August 2020, and based in the Amsterdam Science Park, VectorY is a fully integrated gene therapy company focused on the development of innovative therapeutics for the treatment of neurodegenerative diseases such as ALS and Huntington’s disease. With R&D facilities in Amsterdam, VectorY develops proprietary & partnered programs based on its novel AAV-based vectorized antibody gene therapy platform.

Short description of the Research and Development department

The Research and Development Department designs new technologies and innovations in vectorized antibodies to develop novel treatments for neurodegenerative diseases, with a particular focus on CNS protein opathies. We are testing new therapeutic candidates in in vitro and in vivo pre-clinical settings and models. The Department works towards the clinical translation of these novel therapies. 

Main responsibilities of the role

  • Develop and phase-appropriate qualification/validation of analytical methods

  • Evaluate new bioanalytical methods and implement new equipment and quality standards

  • Plan, coordinate, and participate in bioanalytic activities for Research and Development and Clinical Department

  • Supervises technicians to guarantee the execution and progress of bioanalytical support of the Research projects

  • Ensure timely data analysis, evaluation, and reporting of bioanalytical analysis for nonclinical GLP-Tox studies and (pre-)clinical studies

  • Transfer assays to external partners and CROs, and support assay validation at CRO

  • Communicate and align bioanalytical activities within the group and between departments

  • Write and review bioanalytical SOPs and reports for internal purposes and regulatory documents.

Skills and Qualifications:

  • PhD background in molecular biology, cell biology and/or molecular virology

  • At least 5 years of experience in the industry

  • Possess the technical and scientific knowledge to lead the development and phase appropriate qualification of non-regulated and suitable compliant assays within a regulated environment including validation of methods to ICH

  • Experience in a GxP environment and in-depth knowledge of bioanalytical assays, assay transfer, assay development, qualification, and/or validation

  • Able to maintain, perform, and develop new protocols in laboratory automated systems

  • Experience in techniques such as qPCR, dPCR, ELISA, ADAs, and cell-based assays

  • Knowledge of DoE and statistics used for assay qualification and/or validation is highly preferred

  • A team player with proven experience of working within a high-performing team

  • Ability to manage, train, and mentor junior employees.

Your Natural Strengths and Drivers

You are driven to get things done, by thinking outside of the box. You have an eye for detail and can handle precise work. You can motivate people and work in a team. You take ownership of problems and act with a sense of urgency. You have excellent communication skills and organizational skills.

Working at VectorY

Challenging and varied work with a real impact. We offer an attractive salary package, 30 holiday days, and every opportunity to develop yourself. An authentic experience within a young, ambitious biotech company on the path to bringing innovative therapies to patients worldwide.

Interested? Please apply and send your resume to talent.acquisition@vectorytx.com.